{"id":10815,"date":"2022-10-11T13:54:08","date_gmt":"2022-10-11T05:54:08","guid":{"rendered":"https:\/\/globalhealth.dukekunshan.edu.cn\/news\/%e7%aa%81%e7%a0%b4%e8%80%90%e8%8d%af%e7%93%b6%e9%a2%88-%e6%8a%97%e7%94%9f%e7%b4%a0%e8%80%90%e8%8d%af%e8%8f%8c%e7%a0%94%e7%a9%b6%e5%8f%96%e5%be%97%e6%96%b0%e8%bf%9b%e5%b1%95\/"},"modified":"2024-05-28T13:55:20","modified_gmt":"2024-05-28T05:55:20","slug":"research-makes-ground-on-treating-antibiotic-resistant-infection","status":"publish","type":"gh_news","link":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/news\/research-makes-ground-on-treating-antibiotic-resistant-infection\/","title":{"rendered":"\u7a81\u7834\u201c\u8010\u836f\u201d\u74f6\u9888 \u6297\u751f\u7d20\u8010\u836f\u83cc\u7814\u7a76\u53d6\u5f97\u65b0\u8fdb\u5c55"},"content":{"rendered":"\n<p>\u6606\u675c\u5168\u7403\u5065\u5eb7\u7814\u7a76\u4e2d\u5fc3\u548c\u6606\u675c\u65b0\u5f64\u751f\u7269\u5316\u5b66\u5b9e\u9a8c\u5ba4\u7684\u4e00\u9879\u7814\u7a76\u5728\u63a2\u7d22\u8270\u96be\u68ad\u83cc(C. diff)\u611f\u67d3\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\u3002\u8270\u96be\u68ad\u83cc\u662f\u4e00\u79cd\u6297\u751f\u7d20\u8010\u836f\u83cc\uff0c\u53ef\u5bfc\u81f4\u4e25\u91cd\u8179\u6cfb\u3001\u8179\u75db\u3001\u53d1\u70e7\uff0c\u751a\u81f3\u53ef\u80fd\u81f4\u547d\u3002<\/p>\n\n<p><a href=\"https:\/\/journals.asm.org\/doi\/full\/10.1128\/mbio.01849-22\" rel=\"nofollow noopener\" target=\"_blank\">\u7814\u7a76\u7ed3\u679c<\/a>\u53d1\u8868\u4e8e\u7f8e\u56fd\u5fae\u751f\u7269\u5b66\u4f1a\u671f\u520a\u300amBio\u300b\uff0c\u63ed\u793a\u4e86\u8270\u96be\u68ad\u83cc\u611f\u67d3\u9020\u6210\u7684\u7ec4\u7ec7\u635f\u4f24\u7684\u5173\u952e\u57fa\u56e0\u3002\u76ee\u524d\uff0c\u8270\u96be\u68ad\u83cc\u611f\u67d3\u7387\u5728\u5168\u7403\u8303\u56f4\u5185\u9010\u5e74\u5347\u9ad8\uff0c\u8be5\u7814\u7a76\u6709\u52a9\u4e8e\u5f00\u53d1\u8270\u96be\u68ad\u83cc\u611f\u67d3\u7684\u6cbb\u7597\u836f\u7269\u3002<\/p>\n\n<p>\u6606\u5c71\u675c\u514b\u5927\u5b66\u751f\u7269\u5b66\u526f\u6559\u6388\u9ec4\u6797\u5cf0\u535a\u58eb\u4e3b\u6301\u4e86\u8fd9\u9879\u7814\u7a76\uff0c\u4ed6\u8ba4\u4e3a\uff1a\u201c\u8270\u96be\u68ad\u83cc\u611f\u67d3\u5df2\u6210\u4e3a\u516c\u5171\u536b\u751f\u7684\u91cd\u5927\u5a01\u80c1\u3002\u6211\u4eec\u8feb\u5207\u9700\u8981\u4e86\u89e3\u5176\u611f\u67d3\u673a\u5236\u5e76\u7814\u5236\u9ad8\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ee5\u89e3\u51b3\u8fd9\u4e2a\u5168\u7403\u533b\u7597\u96be\u9898\u3002\u201d<\/p>\n\n<figure class=\"wp-block-image aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2023\/08\/07145903\/image-8.png\" alt=\"\" class=\"wp-image-6233\" srcset=\"https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2023\/08\/07145903\/image-8.png 800w, https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2023\/08\/07145903\/image-8-400x267.png 400w, https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2023\/08\/07145903\/image-8-768x512.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">\u751f\u7269\u5b66\u526f\u6559\u6388\u9ec4\u6797\u5cf0\u535a\u58eb\uff08\u5de6\uff09\u4e0e\u81ea\u7136\u4e0e\u5e94\u7528\u79d1\u5b66\u90e8\u751f\u7269\u5b9e\u9a8c\u5ba4\u8bb2\u5e08\u674e\u8fce\u96ea\u535a\u58eb\uff08\u53f3\uff09<\/figcaption><\/figure>\n\n<p> <\/p>\n\n<p>\u6839\u636e\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\u7684\u6570\u636e\u7edf\u8ba1\uff0c\u8270\u96be\u68ad\u83cc\u662f\u5168\u7f8e\u5f15\u53d1\u4e0e\u6297\u751f\u7d20\u76f8\u5173\u80a0\u9053\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c2017\u5e74\u7ea6\u670923\u4e07\u75c5\u4f8b\uff0c\u6cbb\u7597\u8d39\u7528\u7ea6\u4e3a\u4e00\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\u6b7b\u4ea1\u75c5\u4f8b\u8fbe12,800\u4f8b\u3002\u8270\u96be\u68ad\u83cc\u611f\u67d3\u7387\u4e0a\u5347\u662f\u7531\u4e8e\u5404\u7c7b\u6297\u751f\u7d20\u7528\u91cf\u4e0d\u65ad\u52a0\u5927\uff0c\u4ece\u800c\u4fc3\u4f7f\u4e86\u8270\u96be\u68ad\u83cc\u548c\u5176\u4ed6\u8010\u836f\u83cc\u7684\u53cd\u590d\u53d1\u4f5c\uff0c\u5e76\u4e14\u8001\u5e74\u4eba\u4e0d\u65ad\u8870\u5f31\u7684\u81ea\u7136\u514d\u75ab\u529b\u9020\u6210\u4e86\u66f4\u591a\u7684\u611f\u67d3\u673a\u4f1a\u3002<\/p>\n\n<p>\u9ec4\u6797\u5cf0\u8868\u793a\uff1a\u201c\u901a\u8fc7\u8fd9\u9879\u7814\u7a76\uff0c\u6211\u4eec\u5f97\u4ee5\u4e86\u89e3\u8270\u96be\u68ad\u83cc\u611f\u67d3\u9020\u6210\u7ec4\u7ec7\u635f\u4f24\u7684\u5173\u952e\u57fa\u56e0\uff0c\u8fdb\u4e00\u6b65\u7814\u5236\u80fd\u591f\u7cbe\u51c6\u9488\u5bf9\u8fd9\u4e9b\u57fa\u56e0\u7684\u836f\u7269\u6765\u907f\u514d\u7ec4\u7ec7\u635f\u4f24\u3002\u201d<\/p>\n\n<p>\u7814\u7a76\u4eba\u5458\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u4f7f\u7528\u4eba\u4f53\u80a0\u9053\u7ec6\u80de\u6a21\u578b\u548c\u8270\u96be\u68ad\u83cc\u4ea7\u751f\u7684\u6bd2\u7d20\u6765\u6a21\u62df\u8270\u96be\u68ad\u83cc\u611f\u67d3\u8fc7\u7a0b\uff0c\u56e0\u4e3a\u6bd2\u7d20\u662f\u5bfc\u81f4\u7ec6\u80de\u635f\u4f24\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/p>\n\n<p>\u6606\u5c71\u675c\u514b\u5927\u5b66\u81ea\u7136\u4e0e\u5e94\u7528\u79d1\u5b66\u90e8\u751f\u7269\u5b9e\u9a8c\u5ba4\u8bb2\u5e08\u674e\u8fce\u96ea\u535a\u58eb\u4ee5\u53ca\u7f8e\u56fd\u5eb7\u5948\u5c14\u5927\u5b66\u7b49\u591a\u5bb6\u5b66\u672f\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u53c2\u4e0e\u4e86\u8fd9\u9879\u7814\u7a76\u3002\u674e\u8fce\u96ea\u89e3\u91ca\uff1a\u201c\u6211\u4eec\u5f00\u521b\u4e86\u4e00\u4e2a\u65b0\u578b\u57fa\u56e0\u7b5b\u67e5\u6cd5\uff0c\u5229\u7528\u7ec6\u83cc\u7ec6\u80de\u5236\u9020\u6570\u5343\u4e2a\u7cbe\u786e\u57fa\u56e0\u9776\u5411\u7684RNA\u5206\u5b50\uff0c\u5373\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178(siRNA)\u3002\u7136\u540e\uff0c\u6211\u4eec\u4f7f\u7528\u9ad8\u901a\u91cf\u65b9\u6cd5\u6d4b\u8bd5\u8fd9\u4e9bsiRNA\uff0c\u5e76\u4f7f\u7528\u751f\u5316\u68c0\u6d4b\u548c\u663e\u5fae\u955c\u89c2\u5bdf\uff0c\u63a2\u7d22\u5b83\u4eec\u5728\u8270\u96be\u68ad\u83cc\u6bd2\u7d20\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u4e2d\u7684\u4f5c\u7528\u3002\u6700\u540e\uff0c\u6211\u4eec\u521d\u6b65\u7b5b\u9009\u51fa\u6700\u6709\u53ef\u80fd\u7684\u5019\u9009\u57fa\u56e0\uff0c\u518d\u901a\u8fc7\u5404\u79cd\u5b9e\u9a8c\u5ba4\u6280\u672f\u9a8c\u8bc1\u5b83\u4eec\u53c2\u4e0e\u4e86\u8270\u96be\u68ad\u83cc\u6bd2\u7d20\u8bf1\u5bfc\u7684\u7ec6\u80de\u635f\u4f24\u3002\u201d<\/p>\n\n<p> <\/p>\n\n<figure class=\"wp-block-image aligncenter\"><img decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2022\/10\/07145834\/pic3-800.jpeg\" alt=\"\" class=\"wp-image-7440\" srcset=\"https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2022\/10\/07145834\/pic3-800.jpeg 800w, https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2022\/10\/07145834\/pic3-800-400x267.jpeg 400w, https:\/\/newstatic.dukekunshan.edu.cn\/globalhealth\/2022\/10\/07145834\/pic3-800-768x512.jpeg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">\u81ea\u7136\u4e0e\u5e94\u7528\u79d1\u5b66\u90e8\u751f\u7269\u5b9e\u9a8c\u5ba4\u8bb2\u5e08\u674e\u8fce\u96ea\u535a\u58eb<\/figcaption><\/figure>\n\n<p>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5728\u8270\u96be\u68ad\u83cc\u5bfc\u81f4\u7684\u7ec6\u80de\u6b7b\u4ea1\u4e2d\uff0c\u6709\u51e0\u4e2a\u65b0\u57fa\u56e0\u8d77\u4e86\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5305\u62ec\u5728\u7ec6\u80de\u95f4\u7684\u9ecf\u9644\u4e0a\u8d77\u91cd\u8981\u4f5c\u7528\u7684\u6591\u73e0\u86cb\u767d(plakoglobin)\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u5c55\u793a\u4e86\uff0c\u901a\u8fc7\u4f7f\u7528\u5c0f\u5206\u5b50\u548csiRNA\u6765\u963b\u65ad\u7279\u5b9a\u7684\u57fa\u56e0\u529f\u80fd\uff0c\u6709\u53ef\u80fd\u6cbb\u7597\u8270\u96be\u68ad\u83cc\u611f\u67d3\u3002<\/p>\n\n<p>\u9ec4\u6797\u5cf0\u89e3\u91ca\uff1a\u201c\u963b\u65ad\u57fa\u56e0\u529f\u80fd\u53ef\u51cf\u8f7b\u8270\u96be\u68ad\u83cc\u6bd2\u7d20\u9020\u6210\u7684\u7ec6\u80de\u6b7b\u4ea1\uff0c\u8fd9\u4e2a\u65b9\u6cd5\u770b\u6765\u662f\u53ef\u884c\u7684\u3002\u4e2d\u836f\u5316\u5408\u7269\u7518\u8349\u751c\u7d20(Glycyrrhizin)\u80fd\u591f\u963b\u65ad\u5176\u4e2d\u4e00\u4e2a\u5019\u9009\u57fa\u56e0HMGB1\uff0c\u6211\u4eec\u5728\u7ec6\u80de\u57f9\u517b\u548c\u52a8\u7269\u6a21\u578b\u4e2d\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u5176\u5bf9\u8270\u96be\u68ad\u83cc\u6bd2\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u548c\u7ec4\u7ec7\u635f\u4f24\u5177\u6709\u5f3a\u5927\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u201d<\/p>\n\n<p>\u201c\u7518\u8349\u751c\u7d20\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u809d\u810f\u75be\u75c5\uff0c\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u7518\u8349\u751c\u7d20\u4e5f\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u8270\u96be\u68ad\u83cc\u611f\u67d3\u3002\u201d<\/p>\n\n<p> <\/p>\n\n<p>\u9ec4\u6797\u5cf0\u540c\u65f6\u5f3a\u8c03\uff0c\u4ece\u79ef\u6781\u7684\u7814\u7a76\u7ed3\u679c\u5230\u5b9e\u73b0\u4efb\u4f55\u6cbb\u7597\u65b9\u6cd5\u4e4b\u95f4\u8fd8\u6709\u201c\u5f88\u957f\u7684\u8def\u201d\u8981\u8d70\uff0c\u56e0\u4e3a\u65b0\u836f\u7684\u7814\u53d1\u5fc5\u987b\u9996\u5148\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u8fdb\u884c\u4e25\u683c\u7684\u5b89\u5168\u548c\u7597\u6548\u6d4b\u8bd5\uff0c\u7136\u540e\u518d\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n\n<p>\u7531\u6b64\u51fa\u53d1\uff0c\u9ec4\u6797\u5cf0\u5728\u5168\u7403\u5065\u5eb7\u7814\u7a76\u4e2d\u5fc3\u548c\u65b0\u5f64\u751f\u7269\u5316\u5b66\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u56e2\u961f\u6b63\u4e13\u6ce8\u4e8e\u4f7f\u7528\u81ea\u4e3b\u7814\u53d1\u7684\u57fa\u4e8esiRNA\u7684\u65b0\u578b\u57fa\u56e0\u7b5b\u9009\u6cd5\u7814\u7a76\u5176\u4ed6\u91cd\u8981\u75be\u75c5\uff0c\u5305\u62ec\u4ee3\u8c22\u75be\u75c5\u548c\u764c\u75c7\u7b49\uff0c\u5e0c\u671b\u80fd\u5f00\u53d1\u51fa\u66f4\u591a\u57fa\u56e0\u9776\u5411\u7cbe\u51c6\u533b\u7597\u7684\u5019\u9009\u836f\u7269\u3002<\/p>\n\n<p>\u4f5c\u8005\uff1aJohn Butcher<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6606\u675c\u5168\u7403\u5065\u5eb7\u7814\u7a76\u4e2d\u5fc3\u548c\u6606\u675c\u65b0\u5f64\u751f\u7269\u5316\u5b66\u5b9e\u9a8c\u5ba4\u7684\u4e00\u9879\u7814\u7a76\u5728\u63a2\u7d22\u8270\u96be\u68ad\u83cc(C. diff)\u611f\u67d3\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\u3002\u8270\u96be\u68ad\u83cc\u662f\u4e00\u79cd\u6297\u751f\u7d20\u8010\u836f\u83cc\uff0c\u53ef\u5bfc\u81f4\u4e25\u91cd\u8179\u6cfb\u3001\u8179\u75db\u3001\u53d1\u70e7\uff0c\u751a\u81f3\u53ef\u80fd\u81f4\u547d\u3002<\/p>\n","protected":false},"author":10,"featured_media":6234,"menu_order":0,"template":"","format":"standard","categories":[],"tags":[],"class_list":["post-10815","gh_news","type-gh_news","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/gh_news\/10815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/gh_news"}],"about":[{"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/types\/gh_news"}],"author":[{"embeddable":true,"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/users\/10"}],"version-history":[{"count":1,"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/gh_news\/10815\/revisions"}],"predecessor-version":[{"id":10816,"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/gh_news\/10815\/revisions\/10816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/media\/6234"}],"wp:attachment":[{"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/media?parent=10815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/categories?post=10815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/globalhealth.dukekunshan.edu.cn\/zh-hans\/wp-json\/wp\/v2\/tags?post=10815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}